In the previous few many years, sustainability has change into one of many major challenges of magnificence corporations pushed by rising client demand for extra natural-based cosmetics. Fragrances taking part in a significant function in beauty method, they need to be taken into consideration within the eco-design strategy of cosmetics. The composition of fragrances can suggest as much as 100 completely different perfume substances, however is more often than not saved secret to guard the skilled data of fragance’s suppliers. Completely different eco-design instruments exist, primarily based for instance on inexperienced chemistry ideas and metrics. These instruments could handle numerous environmental impacts or life-cycle steps, from the only E-factor indicator, which focuses on the quantity of waste per quantity of product on the manufacturing step, to an elaborated set of indicators, like within the GREEN MOTION™ software developed by MANE. Alternatively, to evaluate the holistic environmental impacts of merchandise over their complete life-cycle, Life Cycle Evaluation (LCA) is probably the most acknowledged technique. Nonetheless, it requires intensive quantities of knowledge which may be troublesome to acquire or inaccessible for numerous causes, together with confidentiality. To check these completely different potential approaches of fragances eco-design, the outcomes of an LCA of 27 chosen perfume substances are in comparison with these obtained with the inexperienced chemistry software GREEN MOTION™. Perfume substances had been discovered to have a variety of environmental impacts, relying on their manufacturing course of and on the beginning uncooked materials used. General, tendencies noticed on outcomes with the two instruments are in good accordance. This research subsequently showcases the complementarity of simplified eco-design instruments and metrics with LCA to handle environmental impacts of perfume substances. Certainly, the previous can be utilized as a primary strategy to determine environmental hotspots and implement eco-design practices within the improvement strategy of perfume substances, whereas the latter highlights potential direct and oblique impacts over the upstream life cycle and the ingredient manufacturing itself, and can be utilized to measure the discount of the worldwide environmental footprint achieved by the implementation of eco-design practices. Primarily based on these outcomes on perfume substances, a clustering technique might be developed to assist conduct LCA of fragrances.