Significance of Wolbachia-mediated biocontrol to scale back dengue in Bangladesh and different dengue-endemic creating nations

Mosquito-borne ailments, notably dengue and chikungunya have change into international threats, infecting tens of millions of individuals worldwide, together with creating nations of Southeast Asia and Latin America. Bangladesh, like many different creating nations, is experiencing frequent dengue outbreaks. This text, subsequently, critically discusses the present standing of dengue illness, vector management approaches, and the necessity for Wolbachia-mediated intervention in Bangladesh and different dengue-endemic creating nations.

Related literature was searched from main databases and search engines like google and yahoo similar to PubMed, BanglaJol, World Well being Group (WHO)/European Centre for Illness Prevention and Management (ECDC) and Google Scholar. Contemplating the choice standards, search methods lastly concerned 55 associated literature for additional investigation.

Findings confirmed that present vector management methods couldn’t render safety for an prolonged interval, and the illness burden of arboviruses is growing. The impoverished outbreak preparedness, urbanization, local weather change, and fewer efficacy of present management strategies have made folks prone to vector-borne ailments.

Therefore, Wolbachia, a naturally occurring endosymbiont of many mosquito species that may probably restrict virus transmission by means of a number of host genetic alterations, could be a possible different for dengue prevention.

The authors additionally critically talk about the challenges and prospects of Wolbachia-based dengue management in creating nations. The proof supporting the efficacy and security of this intervention and its mechanism have additionally been elucidated.

Empirical proof means that this introgression technique may very well be an eco-friendly and long-lasting dengue management technique. This overview helps policymakers and well being specialists devise a scheme of Wolbachia-based dengue management that may management mosquito-borne ailments, notably dengue in Bangladesh and different creating nations.

The analysis is printed within the journal Biosafety and Well being.