The manufacturing of superior biofuels represents a near-term alternative to decarbonize the heavy car transportation sector. Nonetheless, vital obstacles should be overcome and profitable deployment of those applied sciences would require (i) catalyst and course of growth to scale back price and enhance carbon utilization and (ii) industry-relevant validation of operability to de-risk scale-up. Herein, we search to deal with these challenges for an built-in two-step course of involving catalytic quick pyrolysis (CFP) adopted by co-hydrotreating of bio-oil with refinery streams. Technoeconomic and lifecycle evaluation primarily based on the info offered herein reveal the potential to generate low-carbon transportation fuels and chemical co-products with a modelled promoting worth of $2.83 gasoline gallon equal (2016$) and a 78% discount in greenhouse gasoline emissions in comparison with fossil-based pathways. The feedstock for this analysis was a mix of fifty wt% loblolly pine and 50 wt% waste forest residues, and the CFP step was carried out utilizing an ex situ mounted mattress of Pt/TiO2 with co-fed H2 at atmospheric strain. In comparison with earlier state-of-technology benchmarks, developments in catalyst design and synthesis methodology enabled a 4x discount in Pt loading and a 4x enhance in time on stream with out negatively impacting upgrading efficiency. Moreover, a first-of-its-kind built-in evaluation of waste gasoline adsorption confirmed close to quantitative restoration of acetone and 2-butanone, which collectively symbolize roughly 5% of the biomass carbon. The valorization of those co-products opens alternatives to help decarbonization of the chemical sector whereas concurrently enhancing the general course of carbon effectivity to > 40%. After condensation, the CFP-oil was co-hydrotreated with straight run diesel (10:90 vol%) to realize 95% biogenic carbon incorporation. The oxygen content material of the hydrotreated oil was under detection limits, and the diesel fraction exhibited a cetane quantity and cloud level appropriate for a completed gas. This manuscript concludes by highlighting remaining analysis wants related to enhancing thermal administration throughout catalyst regeneration, mitigating catalyst deactivation resulting from inorganic deposition, and demonstrating sturdiness of biomass feeding techniques when operated in hydrogen-rich environments.